STUDY OF CHARACTERISTICS OF BEHAVIORAL REACTIONS OF RATS UNDER THE CONDITIONS OF EXPERIMENTAL STROKE WITH ANXIETY-DEPRESSIVE DISORDERS

Background. According to the estimates of World Health Organization for 2021, 615 million people (about 10% population world) showed symptoms depressive or anxious disorders. Among main causes death in population, first half year continues suffer from diseases circulatory system, and forecasts indicate a savings trend an increase. Therefore, development anxiety-depressive disorders on aphids ischemic stroke is relevant.
 Aim: investigate specificity TDR experimental eyes.
 Materials methods. Experimental studies were carried out 30 non-linear laboratory tests, which divided into 3 groups: group 1 - contact control, 2 animals with simulated stroke; 3rd blindness modeled The recovery juveniles was performed using additional model endovascular occlusion middle cerebral artery (focal ischemia) by E. Z. Longa. A reserpine-induced depression eyes selected morbidized morbidity pathophysiological lanquences To assess behavioral models we used tests “open field” “apply cross-like labyrinth”.
 Results. Achievements test "chrest-like labyrinth" confirmed increase hour turning dark sleeves labyrinth (a marker increased anxiety) decrease change lighted cottages. Zokrema, stroke, latent period entry chamber growth (p<0.05), as well comorbid pathology (p<0.05) compared intact group.
 There perebuvannya clarified sleeves, number both groups creatures.
 Conclusion. Significant changes psychophysiological noted minds however, pathology, there more manifestations all indications, indicated strengthening anxiety that change. Obtained results require destruction mechanisms depressive-anxious cerebrovascular changes.